The Treatment Referral Center (TRC) was established in 1991 to handle inquiries from physicians seeking treatment options for their patients who had exhausted all standard therapies.  The purpose of the TRC is to make reasonable treatment options available to these physicians and their patients with emphasis on referral to Cooperative Group or Cancer Center studies.  For specified diseases, the TRC identifies those stages and amounts of prior therapy situations for which strong clinical evidence suggests that a new treatment option employing a not yet approved agent should be made available.  These investigational treatment options are made available through the NCI Comprehensive and Clinical Cancer Centers as TRC protocols.  Inquiring physicians wishing to have the investigational treatment for their patient are referred to the closest Cancer Center.