Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity

User-friendly data and

Effective FiO2 Conversion for Infants on Nasal Cannula

In 1994, the NEI funded STOP-ROP (Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity), a randomized controlled clinical trial aiming to test the hypothesis that a carefully controlled increase in oxygen over conventional oxygen management would reduce the proportion of infants progressing from Prethreshold ROP to Threshold ROP.

Throughout the trial, investigators used the method of Benaron and Benitz for calculating effective FiO2 of infants on nasal cannula. For those who wish to use this calculation in their own research or clinical work, we present the Benaron-Benitz conversion, both as printable tables (suitable for bedside use or when no computer is available) and as a JavaScript computer application.

Effective FiO2 Conversion for Infants on Nasal Cannula
Printable Tables Effective FIO2 Calculator

To help support further work in this important area, we have organized and documented a large portion of the STOP-ROP data in a user-friendly format, We offer it here to the research community.


We also give links to further information about the STOP-ROP trial.

More about STOP-ROP
Objective Methods
Results Conclusions
Publications Related Trials

STOP-ROP research was supported by grants from the National Eye Institute, the National Institute of Child Health and Human Development, the National Institute of Nursing Research, several National Institutes of Health General Clinical Research Centers, and local funding sources at many centers.