Human Papillomavirus Working Group


Dr. Joel Palefsky, HPV Chair
University of California, San Francisco


HPV members (From left to right): Dr. David Aboulafia, Virginia Mason Medical Center, Dr. Ronald Mitsuyasu, University of California, Los Angeles; Mr. Jeff Taylor, AMC Community Representative; Dr. Stephen Goldstone, Laser Surgery Care Center; Dr. Elizabeth Stier, Boston Medical Center; Dr. Elizabeth Chiao, Baylor College of Medicine; Dr. Joel Palefsky, University of California, San Francisco; Dr. Mark Einstein, Rutgers New Jersey Medical School.

HPV is the most common sexually transmitted disease, infecting at least 75% of sexually active adults at some point in their lifetime. HPV causes most of the cancers of the anus and cervix, many head & neck cancers, as well as other cancers. The HPV Working Group has done several important studies that have changed the way in which HIV-positive patients with HPV-associated disease are treated. In one clinical study, our group showed that infrared coagulation (IRC) is a well-tolerated treatment of high-grade anal intra-epithelial neoplasia, a precursor to anal cancer.

The current goals of the HPV WG are to:

  1. Evaluate the safety and efficacy of new methods of prevention and treatment of anal and cervical cancers and cancer precursors in HIV-positive patients.
  2. Determine which proteins and genes in the blood and tumor specimens (also known as biologic correlates) will help predict a patient’s prognosis and response to treatment. Knowledge gained from this will be used to develop and test new treatment strategies.
  3. Train clinicians in high-resolution anoscopy to expand expertise and availability of this procedure within the AMC.








Current Protocols:

AMC-088 A Randomized, Phase III Study of Intra-anal Imiquimod 2.5% vs. Topical 5-fluorouracil 5% vs. Observation for the Treatment of High-grade Anal Squamous Intraepithelial Lesions in HIV-infected Men and Women
AMC-092 A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons